Xce Peptides 2mg 5mg 10mg Retatrutide 99% Peptides Vials CAS 1415456-99-3 Sema Tirz Retatrutide for Weight Loss Cagrilintide

• CAS No.: 1415456-99-3
• Formula: C50h69n15o9
• EINECS: 137-1655-0673
• Classification: Biochemical Reagents
• Grade: AR
• Specific Usage: For Biological Purpose, For Tissue Medium Purpose, For Microbiological, For Microscopic Purpose, For Electron Microscopy, For Lens Blooming, Technical Grade, Pratical Use, Pro Analysis, Super Special Grade, For Synthesis, For Scintillation, For Electrophoresis Use, For Refractive Index
• Model NO.: 1415456-99-3
• Content: Standard
• Usage: Laboratory Reagents, Analytical Reagents, Diagnostic Reagents, Teaching Reagents
• Source: Dry Powder
• Habit Appellation: Fine Chemicals
• Application: Industry, Scientific Research, Health, Environmental Protection, Agriculture
• Property: Organic Reagent
• Purity: 99%
• Sensitive: Air Sensitive
• out Packing Size: 200*400
• Documents: COA
• Assay: HPLC 99%
• Transport Package: Box
• Specification: 10vials/kit
• Trademark: Bosetech
• Origin: China
• HS Code: 29225000
• Production Capacity: 50000box/Year

Product Description

Product Description

2mg 5mg 10mg Retatrutide 99% Peptides Vials CAS 1415456-99-3 Sema Tirz Retatrutide for Weight Loss Cagrilintide 

Purity	99%+
Actual peptide content	Exceed the standard
Cleanliness	Sterile
Test Report	COA  HPLC
Customized top color	Red Yellow Blue Black Purple White Green
Custom content	2mg 5mg 10mg 15mg 20mg 30me etc.
Payment method	Bank Transfer BTC USDT Paypal
Transportation time	7-15days
Disguise	Can provide
Resend policy	According to different countries

CagriSema injection is a combination therapy that includes the glucagon-like peptide-1 (GL-1) receptor agonist sema and the long-acting amylin analog cagrilintide . The therapy has weight loss benefits, but the effect on glycated hemoglobin (HbA1c) is unclear.


The 83rd American Diabetes Association Scientific Conference 2023 (ADA 2023) will be held in San Diego, USA on June 23, local time. A study was announced during the meeting, which evaluated the effectiveness and safety of CagriSema (sema combined with canaglitide) in patients with type 2 diabetes. Results showed that in patients with type 2 diabetes, treatment with CagriSema improved glycemic control and resulted in significant weight loss compared with sema or canaglitide monotherapy and was well tolerated with no new safety concerns. sexual signals.

This multi-center, double-blind, phase 2 trial included a total of 92 patients with a body mass index (BMI) ≥27 kg/m2 from 17 research centers in the United States from August 2 to October 18, 2021, who received metformin with or without metformin. Adult patients with type 2 diabetes (HbA1c 7.5%~10.0%) treated with sodium-glucose cotransporter 2 (SGLT2) inhibitors were randomly assigned in a 1:1:1 ratio to receive a weekly subcutaneous injection of CagriSema ( n=31), sema (n=31), or canaglitide (n=30) (dose escalation to 2.4 mg over 16 weeks) for 32 weeks. Of these patients, 59 (64%) were male. The average age of patients was 58 years old. The primary endpoint of the study was the change in HbA1c from baseline. Secondary endpoints were body weight, fasting glucose, continuous glucose monitoring (CGM) parameters and safety.

Primary endpoints:

At week 32, the proportions of patients with HbA1c <7.0% and ≤6.5% were 89% and 75%, respectively, in the CagriSema group, 69% and 48%, respectively, in the sema group, and 69% and 48%, respectively, in the canaglitide group. 33% and 17%. Additionally, the mean change in HbA1c from baseline to week 32 was higher in the CagriSema group than in the canaglitide group (estimated treatment difference [ETD] -1.3 percentage points [95% CI -1.7 to -0.8]; P < 0.0001), but There was no difference compared with the sema group (ETD -0.4 percentage points [95% CI -0.8 to 0.0]; P=0.075).

The average changes in HbA1c in the 3 groups are:

CagriSema group: -2.2 percentage points;

Sema group: -1.8 percentage points;

Canaglitide group: -0.9 percentage points.

Secondary endpoints:

The average change in body weight from baseline to 32 weeks was higher in the CagriSema group than in the canaglitide group (P<0.0001) and the semag group (P<0.0001).


The average changes in body weight of the 3 groups are:

CagriSema group: -15.6%;

Sema group: -5.1%;

Canaglitide group: -8.1%.
The average change in fasting blood glucose from baseline to 32 weeks was higher in the CagriSema group than in the canaglitide group (P=0.0010), but there was no significant difference compared with the sema group (P=0.10).

The average changes in fasting blood glucose in the 3 groups are:

CagriSema group: -3.3 mmol/L;

Sema group: -2.5 mmol/L;

Canaglitide group: -1.7 mmol/L.

At baseline, the CagriSema group, sema group and canaglitide group spent 45.9%, 32.6% and 56.9% of their time within the range of 3.9~10.0 mmol/L respectively, and at week 32 they were 88.9% and 76.2 respectively. % and 71.7%.

 
Adverse events were reported by 21 (68%) subjects in the CagriSema group, 22 (71%) subjects in the sema group, and 24 (80%) subjects in the canaglitide group. The most common adverse events were mild or moderate gastrointestinal disorders. In addition, no grade 2 or 3 hypoglycemic events or fatal adverse events were reported in this study.

Overall, treatment with CagriSema resulted in clinically relevant improvements in glycemic control. The average change in HbA1c in the CagriSema group was greater than that in the canaglitide group, but there was no significant difference compared with the sema group. In addition, patients in the CagriSema group experienced significantly greater weight loss compared with the sema and canaglitide groups and were well tolerated. These data support a longer, larger Phase 3 study of CagriSema in this population.

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Packaging & Shipping

 

Product Packing

1. Usually in bare bottle packaging;

2. 5mg/10mg/15mg per vial, 10 vials/box;

3. The outer packaging is usually a white cardboard box without any labels;

4. We can provide simple text label customization services, without providing colored labels;

5. Generally, a maximum of 25 boxes can be sent per package.

Storage:

Store in tight, light-resistant containers, avoid exposure to direct sunlight, moisture and excessive heat.
Shelf Life: 24 months.

Freeze dried powder can be transported for short distances at room temperature. Once you receive the goods, please immediately store them in the refrigeration room. After mixing with sterile water, it should be used within one week.
 

Packing & Delivery

 

 

 

 

To better ensure the safety of your goods, professional, environmentally friendly, convenient and efficient packaging services will be provided.
We will deliver the goods intact to you by express.
If you want to know the shipping cost, please send an inquiry with your address.
 

Payment & Workshop

 

Company Profile

Hubei Bosi Huike Trading Co., Ltd. is located in Wuhan Donghu High-Tech Economic Development Zone, specilize in production and exportation of pharmaceutical raw materials and intermediates, peptides, cosmetic ingredients, has invested and closed cooperated with domestic manufacturers and Laboratories from famous Universities to meet the different customers' needs from grams to tonnage quantity.

We always stand in high starting, high stand and high quality, and masters strict management for production procedure and quality control. All the products must pass our quality test before being sending to customers.

We have business with more than 60 countries, of which our main markets include Central and South America, Southeast Asia, Central Asia, Africa, Middle East, Eastern Europe, Russia and more and more higher regulative markets are being developed as long as our deep ploughing.

 

What services can we provide?

Accepted Delivery Terms: FOB, CIF, EXW, Express Delivery;
Accepted Payment Currency:USD,EUR,CAD,AUD,HKD,CNY;
Accepted Payment Type: T/T,MoneyGram,PayPal,Western Union,BTC;
Language Spoken: English, Chinese, Spanish, French, German, Portuguese, Russian.

1. We supply Peptides, APIs & Intermediates, Anti-hairloss, Oil, Food Additive and so on to satisfy your needs;
2. We will reply you for your inquiry in 24 hours;
3. Our Q&C team will inspect every product quality strictly before delivery;
4. After delivery, we will track the products for you once every two days, until you get the products. When you got the goods, if you have any questions about the problem, contact with us, we will offer the solve way for you

 

FAQ

Q1: What's your MOQ?
A:MOQ is 1KG.

Q2: How about delivery leadtime?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q3: Is there a discount?
A:Different quantity has different discount.

Q4:How to start orders or make payments?
A:Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Bitcoin.

Q5: How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q6. We don't know you at all, how can we trust you?

A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.Commitment is the No.1 Point of our Enterprise's Value.

Q7.Do you test all your goods before delivery?
A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.