Customization: | Available |
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CAS No.: | 53123-88-9 |
Formula: | C51h79no13 |
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Product name | Rapamycin Sirolimus rapamicina em po Polvo |
CAS No. | 53123-88-9 |
Molecular formula | C51H79NO13 |
Molecular weight | 914.17 |
EINECS number | 610-965-5 |
Purity | >99% Pure |
It is used to coat coronary stents, prevent organ transplant rejection and to treat a rare lung disease called lymphangioleiomyomatosis.
It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants.
It inhibits activation of T cells and B cells by reducing the production of interleukin-2 (IL-2).
Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins.
Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway..
Items | Specifications | Results |
Appearance | White to off white powder | White powder |
Assay (by HPLC) | NLT 97% | 97.64% |
Purity | NLT 97% | 98.15% |
Solvent Residue | ≤0.7% | 0.56% |
NMR (H-NRM) | Conforms | Conforms |
Conclusion: The Product Conforms to Enterprise Standard |
Storage:
Store in tight, light-resistant containers, avoid exposure to direct sunlight, moisture and excessive heat.
Shelf Life: 24 months.
Freeze dried powder can be transported for short distances at room temperature. Once you receive the goods, please immediately store them in the refrigeration room. After mixing with sterile water, it should be used within one week.
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