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Xce Peptides 5mg, 10mg, 15mg Dosage Sema Tirze Retatrutide CAS 1415456-99-3 Weight Loss Peptides Cagrisema
For Biological Purpose, For Tissue Medium Purpose, For Microbiological, For Microscopic Purpose, For Electron Microscopy, For Lens Blooming, Technical Grade, Pratical Use, Pro Analysis, Super Special Grade, For Synthesis, For Scintillation, For Refractive Index
Factory Whole Price 99.5% Purity 5mg, 10mg, 15mg Dosage Sema Tirze Retatrutide CAS 1415456-99-3 Weight Loss Peptides Cagrisema
Product name
Weight Lose Ppetide
Purity
99%
Appearance
White Powder
Storage
Cool Dry Place
Package
1kit, 10kits, 100kits
MOQ
1kit
Shelf life
3 Years
Certificate
ISO 9001 COA MSDS
Payment term
Western Union, Moneygram, Bank Transfer,Wise, BTC
Shipping time
Within 48 hours after Payment
Brand
Lange
Cagrilintide is the newest GL-1R agonist and was approved by the FDA as a once-weekly injection for the
treatmentof T2DM in late 2017. The peptide is chemically similar to liraglu, with the inclusion of two structural
modifications(Lau, Bloch, et al., 2015). The first is the replacement of Gly with the non-proteinogenic amino acid
2-aminoisobutyricacid (Aib) at position 2.
The second is the attachment of octadecanoic diacid to the side chain of Lys-26 through a short polyethylene glycol
(PEG) spacer and a γ-glutamic acid linker. The amino acid substitution renders the peptide more resistant to DPP-4
compared to liraglu, and the presence of the 18-carbon fatty acid moiety results in a high binding affinity for serum
albumin, which translates to a half-life of approximately 7 days in humans.
Primary endpoints:
At week 32, the proportions of patients with HbA1c <7.0% and ≤6.5% were 89% and 75%, respectively, in the CagriSema group, 69% and 48%, respectively, in the sema group, and 69% and 48%, respectively, in the canaglitide group. 33% and 17%. Additionally, the mean change in HbA1c from baseline to week 32 was higher in the CagriSema group than in the canaglitide group (estimated treatment difference [ETD] -1.3 percentage points [95% CI -1.7 to -0.8]; P < 0.0001), but There was no difference compared with the sema group (ETD -0.4 percentage points [95% CI -0.8 to 0.0]; P=0.075).
The average changes in HbA1c in the 3 groups are:
CagriSema group: -2.2 percentage points;
Sema group: -1.8 percentage points;
Canaglitide group: -0.9 percentage points.
Secondary endpoints:
The average change in body weight from baseline to 32 weeks was higher in the CagriSema group than in the canaglitide group (P<0.0001) and the sema group (P<0.0001).
The average changes in body weight of the 3 groups are:
CagriSema group: -15.6%;
Sema group: -5.1%;
Canaglitide group: -8.1%. The average change in fasting blood glucose from baseline to 32 weeks was higher in the CagriSema group than in the canaglitide group (P=0.0010), but there was no significant difference compared with the sema group (P=0.10).
The average changes in fasting blood glucose in the 3 groups are:
CagriSema group: -3.3 mmol/L;
Sema group: -2.5 mmol/L;
Canaglitide group: -1.7 mmol/L.
At baseline, the CagriSema group, sema group and canaglitide group spent 45.9%, 32.6% and 56.9% of their time within the range of 3.9~10.0 mmol/L respectively, and at week 32 they were 88.9% and 76.2 respectively. % and 71.7%.
Adverse events were reported by 21 (68%) subjects in the CagriSema group, 22 (71%) subjects in the sema group, and 24 (80%) subjects in the canaglitide group. The most common adverse events were mild or moderate gastrointestinal disorders. In addition, no grade 2 or 3 hypoglycemic events or fatal adverse events were reported in this study.
Overall, treatment with CagriSema resulted in clinically relevant improvements in glycemic control. The average change in HbA1c in the CagriSema group was greater than that in the canaglitide group, but there was no significant difference compared with the sema group. In addition, patients in the CagriSema group experienced significantly greater weight loss compared with the sema and canaglitide groups and were well tolerated. These data support a longer, larger Phase 3 study of CagriSema in this population.
Clients FeedBack
Packaging & Shipping
Product Packing
1. Usually in bare bottle packaging;
2. 5mg/10mg/15mg per vial, 10 vials/box;
3. The outer packaging is usually a white cardboard box without any labels;
4. We can provide simple text label customization services, without providing colored labels;
5. Generally, a maximum of 25 boxes can be sent per package.
Storage:
Store in tight, light-resistant containers, avoid exposure to direct sunlight, moisture and excessive heat. Shelf Life: 24 months.
Freeze dried powder can be transported for short distances at room temperature. Once you receive the goods, please immediately store them in the refrigeration room. After mixing with sterile water, it should be used within one week.
Packing & Delivery
To better ensure the safety of your goods, professional, environmentally friendly, convenient and efficient packaging services will be provided.
We will deliver the goods intact to you by express.
If you want to know the shipping cost, please send an inquiry with your address.
Payment & Workshop
Company Profile
Hubei Bosi Huike Trading Co., Ltd. is located in Wuhan Donghu High-Tech Economic Development Zone, specilize in production and exportation of pharmaceutical raw materials and intermediates, peptides, cosmetic ingredients, has invested and closed cooperated with domestic manufacturers and Laboratories from famous Universities to meet the different customers' needs from grams to tonnage quantity.
We always stand in high starting, high stand and high quality, and masters strict management for production procedure and quality control. All the products must pass our quality test before being sending to customers.
We have business with more than 60 countries, of which our main markets include Central and South America, Southeast Asia, Central Asia, Africa, Middle East, Eastern Europe, Russia and more and more higher regulative markets are being developed as long as our deep ploughing.
1. We supply Peptides, APIs & Intermediates, Anti-hairloss, Oil, Food Additive and so on to satisfy your needs;
2. We will reply you for your inquiry in 24 hours;
3. Our Q&C team will inspect every product quality strictly before delivery;
4. After delivery, we will track the products for you once every two days, until you get the products. When you got the goods, if you have any questions about the problem, contact with us, we will offer the solve way for you
FAQ
Q1: What's your MOQ? A:MOQ is 1KG.
Q2: How about delivery leadtime? A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q3: Is there a discount? A:Different quantity has different discount.
Q4:How to start orders or make payments? A:Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Bitcoin.
Q5: How do you treat quality complaint? A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q6. We don't know you at all, how can we trust you?
A: You are always warm welcomed to visit us at any time.Before we start B2B, MIC has audited our company on-spot and approved our credit.Commitment is the No.1 Point of our Enterprise's Value.
Q7.Do you test all your goods before delivery? A:Yes, we have 100% test before delivery,International Authorized Third-Party Test for the products if you need are highly welcomed.
