Customization: | Available |
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CAS No.: | 1597403-47-8 |
Formula: | C22h24cl2n2o4 |
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Product Name | Trans ISRIB |
CasNo | 1597403-47-8 |
Content | 99% min HPLC |
Appearance | White powder |
Capacity | 100kgs per month |
Source | synthetic |
Place of Origin | China |
Packing | 1kg/ bag,25kg/ Drum |
Application | For researc,Intermediates |
Trans ISRIB (integrated stress response inhibitor) as a drug, imparts resistance to the cells against the downstream effects of eukaryotic initiation factor 2 (eIF2)α phosphorylation such as activating transcription factor 4 (ATF4) and eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1) induction.
Trans ISRIB is a blood- brain barrier penetrant, potent and selective inhibitor of integrated stress response (ISR) that impairs adaptation to ER stress. Trans ISRIB is a potent inhibitor of PERK signaling, which potently reverses the effects of eIF2a phosphorylation and restores the cells translation capacity. Trans ISRIB enhances cognitive memory in rodents.
Trans ISRIB (integrated stress response inhibitor) has been used as an inhibitor of integrated stress response.
1. Trans ISRIB powder has vasodilating, blood thinning, and memory-enhancing actions.
2. Trans ISRIB powder acts as a cerebral stimulant and vasodilator.
3. Trans ISRIB powder is used to treat arteriosclerosis.
4. Trans ISRIB powder is very effective in curing dementia caused due to insufficient blood supply to the brain.
5. Trans ISRIB powder interferes with cells' ability to synthesize DNA and RNA.
Storage:
Store in tight, light-resistant containers, avoid exposure to direct sunlight, moisture and excessive heat.
Shelf Life: 24 months.
Freeze dried powder can be transported for short distances at room temperature. Once you receive the goods, please immediately store them in the refrigeration room. After mixing with sterile water, it should be used within one week.
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